The Wollongong Roller Hawks have fallen narrowly short of a third straight title in Adelaide.
Taking on unbeaten minor premiers Perth in the grand final on Sunday, the Roller Hawks went down 71-59.
Wollongong led 34-32 at half-time before the Wheelcats lifted the defensive intensity and out-scored their opponents 24-10 in the third quarter.
The Roller Hawks did well to reach the decider after finishing second in the regular season.
After going down to Perth 75-69 in last Friday's major semi-final, they bounced back with a 63-52 defeat of Victoria in Saturday's final to book a title showdown with the Wheelcats.
Despite Wollongong's strong start, the Cats took control in the third period to set up victory.
"Finishing second in the national league is a great feeling when there is so much talent in the league," Roller Hawks club president Pablo Jimenez said.
"Being the only regional team in the league, it shows how good the talent and development is of wheelchair basketballers in this region."
Paralympian Brett Stibners was the standout for Wollongong, averaging 21 points, 8.4 rebounds and six assists over the finals weekend.
Nick Taylor scored 15 points per game, Shawn Russell averaged 12.7 points and 7.7 rebounds, while Luke Pople chipped in almost 10 points per game.