About 10.20am a 22-year-old man was riding a red Yamaha R6 motorcycle along the Illawarra Highway when he lost control and fell onto the road.

His motorcycle continued to slide along the road hitting an oncoming black Mazda 3 before coming to rest in a ditch.

Police and paramedics attended the scene and the man was airlifted to Liverpool Hospital where he remains in a stable condition with suspected internal injuries.

The highway was closed for more than five hours while police conducted examinations of the scene and seized the motorcycle for mechanical inspection.

A 33-year-old man, who was driving the Mazda, was not injured during the collision.

Investigations into the matter are continuing.

Police are urging anyone with information about this incident to call Crime Stoppers on 1800 333 000.