A focus on removing roadside hazards along Appin Road is one of several recommendations of a newly released safety study.
Roads Minister Duncan Gay commissioned the road safety review in December 2012 after a number of fatalities on the road, which stretches from Bulli Tops in the south to Rosemeadow in the north.
The study, by the Centre for Road Safety in conjunction with Roads and Maritime Services (RMS), identified five fatalities on the road over the review period of 2007 to 2012.
Since then there have been three more deaths on the road.
The report divides the road into two sections: between Bulli Tops and Appin (section one) and Appin to Rosemeadow (section two).
"The predominant crash type in section one is run-off-road crashes, which make up 56 per cent of all crashes," it states.
"In most cases these crashes also resulted in the vehicle impacting with an object near [the] roadside, most commonly a tree. All of the fatal crashes over the last five years [to 2011-12] have occurred in this section."
The report also highlights the curves north-west of the Loddon River bridge, where two deaths and a number of crashes causing injury have occurred.
Due to the number of off-road crashes in this area, the report recommended relocating or removing roadside hazards to create "clear zones" or installing safety barriers.
Other recommendations include upgraded and consistent signage, improved line-marking and enhanced road-user behavioural campaigns.
Releasing the report on Monday, Mr Gay said the government would increase spending on Appin Road.
The government has already allocated $745,000 to improve the road surface by July this year.
Mr Gay said a further $100,000 would be spent on upgrading signage and line markings along the entire route.
The minister also announced that RMS would investigate extra safety work over the next few months.
This included further road surface improvements to address wet-weather crashes and an assessment of the safety of overtaking options.