3.45pm: All southbound lanes have been reopened. However, traffic remains extremely heavy and is queued back 15km. Northbound lanes remain unaffected as a contra flow was not put in.
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Paramedics are on scene at a serious crash north of Mittagong on the Hume Highway which left two patients trapped.
Paramedics are helping two people injured in a car crash at Mittagong.
The crash happened about 1.40pm on Thursday.
A NSW Ambulance spokesman said one patient had been freed, while the other remained trapped at 2.15pm.
He said an ambulance helicopter was en route to the scene.
The highway's southbound lanes have been closed, and motorists have been urged to avoid the area.
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