Police are investigating a fatal crash near Bargo on Monday morning.
Police said the crash occurred about 7.30am when a Holden Commodore crossed the central nature strip of the Hume Highway and collided with a B-double prime mover travelling in the opposite direction.
The 23-year-old woman driving the Holden died at the scene.
The 57-year-old male truck driver was uninjured and taken to Bowral Hospital for mandatory blood tests.
Part of the highway was closed for several hours.