Updated 10.30am: The 28-year-old woman who was killed in Tuesday’s horrific car crash on Appin Road has been identified as Hill Top resident Rene White.
Police said Ms White lost control of her car and collided with an oncoming vehicle about 3pm.
The 67-year-old female driver of the second car was flown to St George Hospital in a serious condition.
The fatality occurred on a section of the notorious road identified as a black spot in a Roads and Maritime Services report in March. Police said they were investigating whether wet weather was a factor in the crash.
EARLIER: Police are investigating whether wet weather was a factor in the death of a 28-year-old woman who lost control of her car while driving south on Appin Road about 3pm on Tuesday.
The woman's car collided head-on with a second vehicle before coming to rest in bushland off the notorious section of road, about 1.8 kilometres north-west of Loddons Creek.
The driver of the second vehicle, a 67-year-old woman, was trapped in her car for almost an hour following the crash.
She suffered injuries including a fractured left arm and was flown to St George Hospital in a serious condition.
Campbelltown police inspector Tara Norton said it was a tragic event.
"There's going to be trauma for families across a number of suburbs," she said.
"Unfortunately the weather conditions may have contributed.
"This roadway can be [dangerous] in certain conditions - obviously the rain is something we will need to look at whether or not that was a contributing factor to the accident."
In 2011, the same section of road claimed the life of 21-year-old Ashleigh Connor, who was on her way home to Rosemeadow after her weekly football training session in Wollongong was cancelled due to bad weather.
Tuesday's crash was just metres from a roadside memorial dedicated to Ashleigh.
In March 2014, a Roads and Maritime Services report identified four danger spots for fatal crashes along Appin Road, including a 200-metre section of road where Tuesday's crash occurred.
At the time, there had been a total of 10 crashes in the section - two of which were fatal, with speed being a factor in both.
There were also four crashes that occurred in the section in wet weather.
Tuesday's crash closed Appin Road between Appin and the M1 Princes Motorway for several hours while emergency crews worked to salvage the vehicles.
Crash timeline from Tuesday
9.25pm: Appin Road has been reopened after an earlier fatal car accident and traffic is flowing in both directions.
6.15pm: Police have corrected their earlier report that a male had been killed in the accident and have just now confirmed the driver of the southbound vehcle killed was a 28-year-old woman. CIU officers remain at the scene and the road is still closed in both directions.
5.05pm: Police have now confirmed the 28-year-old male driver of a southbound vehicle appears to have lost control and collided head-on with the vehicle being driven by the 67-year-old woman. Inspector Tara Norton from Campbelltown police says Crash Investigation Unit (CIU) officers will remain at the scene to determine the exact cause of the accident and if weather conditions at the time contributed to the incident. Insp Norton also confirmed the male driver was killed in the accident and the female driver was currently undergoing treatment for her injuries at St George hospital. Appin Road remains closed in both directions.
4.30pm: The 67-year-old woman is currently being flown by NSW Ambulance helicopter to St George hospital in a serious condition.
4.01pm: The 67-year-old woman, who was trapped, suffered a fractured left arm after being compressed in the car. She is in a serious but stable condition.
3.56pm: Police said the two cars collided head-on. The person who was killed was the driver of one of the vehicles.
3.55pm: The trapped woman has been freed and was loaded into a road ambulance.
3.50pm: The trapped woman is believed to be in her 60s and has suffered abdominal and pelvic injuries and a possible fractured arm. Fire fighters are still working to free her from the crash.
3.48pm: An Ambulance NSW spokeswoman confirmed one person has been killed in the crash. A female is still trapped and is expected to be released in about 10 minutes.
The NSW Ambulance helicopter has arrived.
3.40pm: Fire fighters are working to free a person trapped in the accident.
3.35pm: The Transport Management Centre said Appin Road is expected to be closed in both directions for some time due to the serious nature of the crash.
3.30pm: It is believed a person has died in the crash.
3.20pm: Westbound traffic on Appin Road, two kilometres west of the Princes Motorway, is closed after a car crash.
Traffic at Cataract is being diverted through Picton Road or Heathcote Road.
Emergency services and Roads and Maritime Services are at the accident.