The Gilmore electorate is one of the state's top-five stroke hot spots, according to a new report.
In an Australian-first, the National Stroke Foundation has mapped the impact of stroke across the country - leaving no postcode untouched.
The report reveals there are 3718 stroke survivors living in Gilmore, which extends from Warilla south to Durras.
The electorate is the state's second-worst for the condition, with the electorate of Lyne on the Mid North Coast leading the list.
The report says about 450 strokes and 100 deaths from stroke are expected in Gilmore in 2014.
The statistics are well above the national average, as are the figures for the electorates of Cunningham and Throsby.
According to the report, Stroke in Australia: No postcode untouched, there are 3218 stroke survivors living in Cunningham, with about 400 strokes expected to be recorded in the electorate this year.
It is a similar story for Throsby, with 3291 stroke survivors and about 400 strokes expected in 2014.
The report, which used data by Deloitte Access Economics, reveals that almost 440,000 Australians are living with the impact of stroke. Nearly 150,000 of those are in NSW.
NSW National Stroke Foundation executive officer Greg Cantwell said the state's greatest risk factors for stroke included high cholesterol (26 per cent of the population), high blood pressure (18 per cent) and physical inactivity (45 per cent).
"Our report shows that no postcode is untouched by stroke," Mr Cantwell said. "Stroke kills more women than breast cancer and more men than prostate cancer. This devastating disease also places significant demands on health services, families and the community across the country."
He said the report identified where stroke was having the biggest impact and where stroke survivor support was most vital.
"By ranking electorates, we can understand where the impact is greatest. While this ranking can help with service planning and co-ordination, our report demonstrates that the burden of stroke is significant in all parts of the country," Mr Cantwell said.