Hollywood legend Lauren Bacall has died of a massive stroke at her home in Los Angeles on Tuesday morning, according to US media.
TMZ quoted a family source and trade website The Hollywood Reporter has since confirmed her death.
Bacall was born Betty Joan Perske on September 16, 1924. The 89-year-old star of more than 60 films was best known for her distinctive husky voice.
With deep sorrow, yet with great gratitude for her amazing life, we confirm the passing of Lauren Bacall. pic.twitter.com/B8ZJnZtKhN— BogartEstate (@HumphreyBogart) August 12, 2014
Bacall was the star of dozens of films from Hollywood's "golden age", including The Big Sleep (1946), Dark Passage (1947), How to Marry A Millionaire (1953) and Key Largo (1948).
When she made her film debut - at the age of 19, playing opposite her future husband Humphrey Bogart in the film To Have and Have Not - her star exploded in Hollywood.
In the film, Bacall spoke the now-legendary flirtacious line which stayed with her throughout her career: "You don't have to say anything, and you don't have to do anything, not a thing," she said. "Oh, maybe just whistle. You know how to whistle, don't you, Steve? You just put your lips together and ... blow."
Bacall married twice, first to Bogart in 1945 until his death in 1957, and later to actor Jason Robards jnr in 1961.
She had three children, Stephen Humphrey Bogart and Leslie Bogart, and Sam Robards.
As well as a high-profile stage and film career, Bacall was politically active.
In 1952 she campaigned for Democratic candidate Adlai Stevenson in the US presidential elections, and in 1964 she campaigned for Robert Kennedy in his run for the US senate.
She retained her distinct political voice throughout her life; in 2005 she told interviewer Larry King she was "the L word", referring to "liberal".
Bacall was one of Hollywood's most honoured actresses, first winning a Tony Award in 1970 for her role in the musical Applause.
In 1997 she won a Screen Actors Guild award, a Golden Globe and the San Diego Film Critics Society award for her work on The Mirror Has Two Faces.
In 1993 she was the recipient of the Cecil B. DeMille honorary Golden Globe award and in 2009 was the recipient of an honorary Academy Award.
During her life, Bacall wrote two autobiographies, Lauren Bacall By Myself, which was published in 1978, and Now, which was published in 1994.