Penrith captain Matt Moylan won't play again before the NRL finals after suffering another hamstring strain in Sunday's win over Canberra.
Moylan has battled hamstring woes throughout the second half of the season, but it's understood the latest injury in a new one as Penrith look to press their top four claims.
The 26-year-old will miss at least two weeks with a minor strain, and will be replaced by youngster Tyrone May in the No.6 jersey for Sunday's crucial clash with St George Illawarra.
Moylan's absence will be offset by the return of Peter Wallace, who has battled a hand injury in the past week.
It comes as Panthers halfback Nathan Cleary continues his stunning NRL form.
Cleary goes head to head with Dragons No.7 Kurt Mann, who has played at fullback, wing, centre and halfback, as well as utility bench spot since joining St George Illawarra.
Cleary has 206 points this season, including 14 tries, the leading pointscorer ahead of Dragons captain Gareth Widdop on 179.