Just before 7am, a member of the public came across an overturned car off the side of the Old Hume Highway and called police.

Officers from The Hume Local Area Command found the Ford Falcon.

The driver was dead inside the car. There were no other passengers.

"A crime scene was established and initial investigations have led police to believe the vehicle left the roadway, hit a tree before rolling," police said.

Authorities closed the road for four hours while detectives and crime scene officers examined the scene.

A report will be prepared for the Coroner.