An Adelaide hospital is the first to benefit from a customised 3D bioprinter made in Wollongong that promises to revolutionise treatment for people with Type 1 Diabetes.
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Researchers at the University of Wollongong have designed and built the printer which will be capable of delivering insulin-producing islet cells from a protective bioink into a printed scaffold suitable for transplant.
On December 6, ARC Centre of Excellence for Electromaterials Science (ACES) executive director and ANFF Materials director, Professor Gordon Wallace, officially handed over the Pancreatic Islet Cell Transplantation (PICT) 3D Printer to South Australian Minister for Health Peter Malinauskas for use at the Royal Adelaide Hospital (RAH).
The RAH is the first hospital in Australia to receive this cutting edge biomedical printing device, developed by researchers from ACES and ANFF Materials, headquartered at UOW.
The PICT Printer will allow us to make customised organs, mixing donor with recipient cells in a unique 3 Dimensional way to provide completely new composite “organoids” for experimental transplantation.
- Professor Toby Coates
The PICT Printer will be developed further with funding from an Australian Research Council’s Linkage, Infrastructure, Equipment and Facilities (LIEF) grant.
Professor Wallace said the development and hand over of the PICT Printer marked a new era in manufacturing.
‘’ACES at the University of Wollongong has built a collaborative clinical research network that enables us to tackle big clinical challenges and deliver practical solutions using 3D bioprinting,’’ Prof Wallace said.
‘’In collaboration with Professor Toby Coates’ team at Royal Adelaide Hospital, we plan to improve the effectiveness of islet cell transplants by encapsulating donated islet cells in a 3D printed structure, to protect them during and after transplantation.’’
Professor Toby Coates, the Director of Kidney and Islet Transplantation at RAH, said being at the forefront of research gave hope to those living with Diabetes.
‘’The PICT Printer will allow us to make customised organs, mixing donor with recipient cells in a unique 3 Dimensional way to provide completely new composite “organoids” for experimental transplantation,’’ Professor Coates said.
Currently only the most severe cases of Type 1 Diabetes can be treated with islet cell transplantation from human donors.
These donor islet cells restore the diabetes sufferer’s ability to produce insulin and regulate their blood sugar levels.
Prof Wallace said the printed transplant material has the potential to reduce the likelihood of rejection as a patient’s own cells could be used.
Also, because multiple cell types can be printed in the same run, endothelial cells – essential for installing blood flow to the grafted islet cells – can be implanted, improving islet cell survival.
