Two people were seriously injured in the crash.

2.55pm: A NSW Ambulance spokeswoman said the two occupants were taken to Moruya Hospital.

2pm: Civil Aviation Safety Authority spokesman Peter Gibson said a Cessna C210 engine failed while it was cruising and the aircraft hit the ground.

Mr Gibson said two people were on board and sustained serious injuries. There was substantial damage to the aircraft.

1.55pm: Moruya SES crews were at the scene on stand-by to assist, but occupants had been taken out of the plane.

Moruya SES spokesman Jeff McMahon said a plane had crashed about 800 metres short of the runway in shrubbery.

He said there was no smoke or fire.

He said police, paramedics, Fire and Rescue, RFS, council staff and airport management were assisting.

1.45pm: A NSW Police spokesperson confirmed an aircraft crash has occurred at the Moruya Aerodrome just after 1pm and some of the occupants were injured. Police were still at the scene at 1.45pm.

1.30pm: A NSW Ambulance spokesperson said two people were on board the aircraft and it is understood one or both patients were being treated for serious head injuries.

She said three ambulance crews were on scene and a helicopter was on route.

The patients were continuing to be assessed at 1.30pm.

1.22pm: Batemans Bay Fire and Rescue captain Paul Lyons said crews were on their way to an aircraft crash near Moruya Airport.

Several Batemans Bay police vehicles rushed to attend.