Police believe the man riding a BMW motorcycle crossed onto the wrong side of the road in front of a Toyota sedan on Moss Vale Road, Barrengarry at about 7.20am.

Paramedics treated the man at the scene but he later died.

The 56-year-old male driver of the Toyota did not suffer any injuries and was taken to hospital for mandatory blood and urine testing.

Shoalhaven police are investigating the incident and will prepare a report for the coroner.