Jarryd Hayne and Chris Sandow have inspired Parramatta to a 42-24 win over Cronulla in an action-packed NRL clash at Pirtek Stadium on Monday.

The pair scored three tries between them, with one of Hayne's a contender for the season's best as the Eels secured their fifth win of the season - matching their total for last year.

Cronulla's disappointing evening was compounded by an early injury to Andrew Fifita, with the NSW prop limping off with ankle syndesmosis early in the game which could potentially rule him out of the NSW side for the State of Origin opener on May 28.

Eels winger Semi Radradra opened the scoring after four minutes when he latched on to a bullet-like pass from Hayne.

But the Sharks hit back immediately with a Sosaia Feki try converted by Michael Gordon.

Wade Graham then showed some brilliant soccer skills by chipping Jeff Robson's grubber kick over the head of two Eels defenders then regathered to score.

However, that moment of magic was eclipsed by Hayne midway through the opening stanza, with the superstar fullback stepping past five players to power his way over the line.

Will Hopoate appeared to have restored the Eels' lead but the video referee backed the decision of the on-field officials to deny the try despite the centre looking to have grounded the ball.

But the Eels' dismay was short-lived with Sandow hauling in his own chip and chase to score under the posts before winger Ken Sio increased the hosts' advantage before half-time.

The Sharks were much improved in the second period despite Hopoate's try for the Eels just after the restart.

Inspired by a brilliant run and pass from skipper Paul Gallen, Isaac De Gois got on the scoresheet.

However their hopes of a come-from-behind win were ended by Willie Tonga's 90-metre intercept try in the 63rd minute, with Sio grabbing his second following some good work from Hopoate.

Fittingly, Hayne had the final word, racing almost the length of the field after a sloppy Blake Ayshford pass. AAP