Lawrence Hargrave Drive at Stanwell Tops will close on two days this week for essential maintenance work.
The road will be closed between 9am and 3pm on Monday and Tuesday, weather permitting.
The closure affects motorists in both directions between Stonehaven Road and Lady Wakehurst Drive.
A detour will be in place via Walker Street and Otford Road; motorists should allow up to 15 minutes additional travel time.
Road and Maritime Services says motorists should plan their journey outside of the road closure times or travel via the detour routes.
For the latest traffic updates download the Live Traffic NSW App, visit livetraffic.com or call 132 701.