Police were called to the Sanctuary Point home around 9.20pm, after reports of a stabbing.

On arrival officers found the man suffering a “single puncture wound” to his shoulder.

Police and NSW Ambulance paramedics started CPR at the scene but he died on the way to hospital.

The woman was arrested at the scene before being taken to Nowra Police Station where she assisted detectives from South Coast Police District with their inquiries.

The woman spoke with officers for most of Tuesday morning before being charged with manslaughter and granted conditional bail.

She will appear in Nowra Local Court on Friday, September 14.

The woman was taken from the station, covered in a blanket, in the rear of a police detective's car.

In a press conference at Nowra Police Station, South Coast Police District Area Command Inspector Deborah O'Reilly said the incident was domestic related.

“It is understood there was a verbal altercation that led up to the stabbing incident,” Insp O’Reilly said.

“But I’m not able to describe the details any further than that.”

She confirmed the woman and man were mother and son.

It is understood the woman might have been under duress at the time of the incident, although Insp O’Reilly would not comment on that line of questioning, or if there had been a history of violence between the pair or if the victim was known to police prior to the incident.

“I’m not able to comment on such matters, that will come out in court,” she said.

Insp O’Reilly said she was unsure who made the call to emergency services for help but confirmed two other adults, the woman’s husband and the dead man’s partner, were at the home at the time of the incident.

“The adults were spoken to by police at Huskisson Police Station,” Insp O’Reilly said.

“Certainly they are upset understandably, as is the woman - we are looking after their welfare.”