The quake onn Friday sent out tremors felt as far afield as Libya, Italy, Malta and Albania. Greek authorities initially issued a tsunami warning then withdrew the alert.

The magnitude 6.4 quake struck in the Ionian Sea, 50km south of the island of Zakynthos, also known as Zante, Greece's Geodynamic Institute reported. The US Geological Survey rated the magnitude at 6.8.

Three people were taken to hospital on the island, two of them slightly injured, a spokesman for Greece's civil protection agency said. A series of aftershocks, the highest at 5.6, rattled the island and power was briefly disrupted.

Tremors damaged a 15th-century monastery on the nearby islands of Strofades, local media in Zakynthos reported. They also left large cracks in the port of Zakynthos, though authorities there said operations would continue as usual.

Extensive damage was avoided because quake-prone Zakynthos had adopted seismic protection codes in construction, said Efthymios Lekkas, head of Greece's Earthquake Planning and Protection Organisation said .

"The energy unleashed, based on the angle of the faultline, fanned out towards Italy," he added.

Italy's Il Messaggero online news site said the quake was felt hundreds of kilometres away in southern Italy. Firefighters in Calabria, Puglia and Sicily received thousands of telephone calls from worried locals.

Zakynthos was all but destroyed in a 6.8 tremor in 1953. More than 140 people were killed in an earthquake north of Athens in 1999.

The quake was fairly shallow, according to the USGS, just 14km below the seabed, which would have amplified shaking.

It struck at 1.54am on Friday (9.54am AEDT) Greece straddles two tectonic plates and often suffers earthquakes.

The EMSC European quake agency said sea levels had risen slightly, by about 20cm, but the increase could be higher locally.

It later tweeted sea level changes were also observed in Italy.

Australian Associated Press