A driver is dead and another has been airlifted to hospital following a two-truck crash on Picton Road near Wilton.
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Picton Road fully reopened about 1.30pm on Wednesday. It was closed for four hours after the crash.
The head-on collision occurred near MacArthur Drive at about 3.40am.
The driver of a table-top truck died at the scene.
The 38-year-old male driver of a car carrier was trapped in the truck for about an hour.
NSW Ambulance has since been taken to Liverpool Hospital by helicopter suffering from a head injury.
Motorists were being diverted onto other major roads but those diversion have been lifted.
Police crash investigators assessed the site.