Australian captain Jess McCall will lead an injury-hit Wollongong State Cup squad at Port Macquarie.
The Devils are without Sophie Broadhead, Nikki Stanley and Lauren Rynehart for the tournament.
However, Wollongong vice-president Tim Robinson is optimistic about their finals chances when action starts on Friday.
NRL premiership players Nathan Fien and Jamie Soward will be part of the men’s over 30s squad, the first time Wollongong has played in the division in several years.
Wollongong will also have a men’s opens team, hoping to improve on a quarter final finish last year, and a division one team.
“Wollongong is excited to be sending away four strong teams to the 2018 State Cup. It's an event every team looks forward to each year and take very seriously," Robinson said. “It's been a long time since Wollongong has won a State Cup title, the last was the men's Premier League in 2012. We definitely have four teams which can challenge.
"It’s great to see some of the Devils youth coming through this year.
“Four players under the age of 18 will represent Wollongong in open divisions, which is a great mix in with the experience on hand."
The men’s opens take on Bankstown Sports, Canterbury, Ryde-Eastwood, Penrith, Wests Magpies and a representative team from England in their pool.
The women’s opens competition features 10 teams, including six from Sydney, Newcastle, Central Coast and England. The favourites in the men’s over 30s are defending champion Murwillumbah, featuring ex-NRL star Scott Prince.