The second one day international between West Indies and Ireland originally scheduled for Tuesday has been postponed due to COVID-19 cases and injuries in the tourists' squad, both teams said in a joint statement.
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Ireland reported two further positive cases while two players were ruled out due to injury, with five players in total isolating.
Paul Stirling, Simi Singh and Ben White tested positive last week and missed the first ODI on Saturday, which West Indies won by 24 runs.
"CWI and CI are in discussions to review the match schedule and are working to explore all possibilities for the series to be completed," a joint statement read.
The two teams are scheduled to meet in the third ODI on Friday before the tour ends with a one-off Twenty20 international in Kingston on Sunday.
The Ireland squad headed for Jamaica at the end of last month after their one-day international series against the United States from December 26-30 was cancelled due to positive coronavirus cases ,initially among the match officials.
A member of the Ireland staff and several US players then tested positive before cases spread and both teams came to be considered close contacts.
The two teams had played a T20 series in Florida which ended 1-1.
Australian Associated Press