This deadly stretch runs from just north of the Cordeaux dam turn-off to two kilometres north of the MacArthur Drive intersection.

A section of it features concrete medians but long swathes of the route is single lane with nothing but two yellow lines separating traffic.

The seven deaths come from five crashes - all of which were head-on collisions.

One collision occurred while a vehicle was overtaking.

One of the only deaths on Picton Road outside this horror six-kilometre stretch in the last five years was a 2014 crash at the Hume Motorway intersection - which led to the installation of traffic lights.

The other was a 2018 single-car crash when Riana Martelli ran off the road near the Cordeaux dam turn-off.

The southern end of Picton Road has not seen any fatalities since 2014, which could be put down to the $53 million spent on 15 individual road projects - the last of which was completed in 2013.

The vast majority of those projects occurred at the southern end.

By comparison, the northern end has seen relatively little work.

Accelerating lanes from rest areas just outside the six-kilometre fatality cluster were completed last year.

This year Roads and Maritime Services announced plans to build 600 metres of jersey barriers to link up to those already existing west of Cordeaux colliery.

But neither of these projects fall within the six-kilometre danger zone.

"The installation of the safety barriers currently being carried out at Cordeaux is the result of Roads and Maritime Services' ongoing safety assessments of the corridor," a Roads and Maritime Services spokeswoman said.

"Roads and Maritime Services is developing further road safety improvements on Picton Road, which will include more safety barriers, widened centre lines and audio tactile line marking."

However, the spokeswoman declined to state whether any of the planned works would be within the deadly six-kilometre stretch.

Every year since 2014, the same horror stretch of Picton Road has claimed at least one life.

2014: Two people die when their Mitsubishi Colt collides with a silver Mazda 626 on September 5.

The 66-year-old female driver and her 68-year-old male passengers were from Deniliquin in the state's south-west.

The 18-year-old driver, the only occupant of the Mazda, was airlifted to Liverpool Hospital in a serious condition.

2015: At 7.30pm on September 15, a 64-year-old Mt Pleasant woman dies in a head-on collision.

Her sister was also in the car and was taken to hospital in a serious but stable condition.

2016: A man driving a 4WD is killed on February 7 after his vehicle is clipped from behind by a ute and then crosses over onto the other side of the road, where he collides head-on with a jeep.

2017: A fiery head-on collision in the early hours of March 24 claims the lives of truck drivers Michael Gorman and Adrian Ryan.

Mr Ryan's B-double veered onto the wrong side of the road.

Mr Ryan was driving for company A Fife and Co at the time.

Earlier in June company director Peter Fife was fined $88,000 and ordered to pay $30,000 in costs after a court ruled there had been numerous offences relating to driver fatigue and breaches in the chain of responsibility.

2018: Shortly before 4am on November 14, the 39-year-old driver of a Mitsubishi Canter table-top truck dies in a head-on collision with a car carrier.

The driver of the car carrier - a 38-year-old man - was trapped in his cabin for 90 minutes before being freed and airlifted to Liverpool Hospital.