Man killed, another airlifted after horror two-vehicle crash in Cataract

The collision between a sedan and a van occurred on Picton Road, at the intersection of Mount Keira Road, around 1.30pm on Friday, February 2.

The male driver of the sedan died at the scene. He is yet to be formally identified.

The male driver of the van suffered serious injuries and was airlifted by NSW Ambulance rescue helicopter to St George Hospital, in a stable condition.

NSW Police Acting Inspector Jayson Joerdens said there was a "substantial impact" between the two vehicles.

"At this stage it's still under investigation, we've got our crime scene in attendance at the moment and they'll have a look at all the circumstances around the crash," he said.

Acting Insp urged people to drive to the conditions and be "patient and cautious while on the road".

"The impact is far-reaching, not just for the people involved in the crash, but we've had to shut down Picton Road at the moment, in both directions."

Picton Road reopened about 6pm.

Emergency services, including police forensic officers, remain at the scene and police will prepare a report for the coroner.